VIP research: quick summary
VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide of the secretin/glucagon superfamily, studied at the VPAC1 and VPAC2 receptors. Its circulating half-life is roughly two minutes, which shapes every study design built around it. This Canadian product listing concerns laboratory research material only. It is not an authorized medicine, does not provide dosing or administration instructions, and is not intended for human or veterinary use.
VIP Canada: VIP 10mg Research Product
VIP Canada researchers can order a 10mg vial of vasoactive intestinal peptide directly from Red Leaf Research Labs, with published analytical information, Canadian-dollar pricing and domestic express fulfilment.
For searches such as buy VIP peptide Canada, vasoactive intestinal peptide 10mg or VPAC receptor agonist, this page sets out the molecule, its receptor targets, and the one property that determines whether a given experiment with it is feasible at all.
Red Leaf Research Labs supplies research material to qualified purchasers in Canada. Nothing on this page describes a therapy, a treatment or a permitted personal use.
VIP 10mg Research Format
| Attribute | Detail |
|---|
| Research format | VIP 10mg, single vial |
| Physical state | Lyophilized powder |
| Analytical documentation | Third-party report available for the current lot |
| Fulfilment | Domestic Canadian express shipping |
| Intended use | Qualified laboratory research only |
VIP Research Specifications
- Compound name: Vasoactive intestinal peptide
- Common abbreviations: VIP, vasoactive intestinal polypeptide
- Class: Neuropeptide of the secretin/glucagon superfamily
- Length: 28 amino acids
- Species note: The human, porcine and rat sequences are identical, so a report specifying one of these is not describing a different molecule
- CAS number: 37221-79-7 — note that alternative registry numbers appear in supplier catalogues, so confirm the number against the sequence rather than the reverse
- Molecular formula: C147H237N43O43S
- Approximate molecular weight: 3.3 kDa
- Receptor targets: VPAC1 and VPAC2 — class II G protein-coupled receptors
- Circulating half-life: approximately two minutes
- Physical format: Lyophilized powder
- Intended use: Qualified laboratory research only
The Two-Minute Half-Life Is the Whole Design Constraint
Most listings for VIP mention its receptor targets and stop. The number that actually determines what you can do with it is the half-life: roughly two minutes in blood circulation.
For in-vitro work this is largely irrelevant — a receptor-binding or cell-signalling assay operates on timescales where VIP behaves normally, and VPAC1/VPAC2 pharmacology is well characterised in exactly those systems. For any whole-organism design it is decisive. A peptide cleared in minutes cannot produce a sustained systemic exposure, which is why the translational literature in this area is dominated by engineered analogues, sustained-release formulations and delivery strategies rather than by native VIP.
A laboratory planning work with this compound should settle early which of those two worlds the experiment lives in. Native VIP is an excellent receptor-pharmacology tool and a poor systemic agent, and no handling procedure changes that.
What VIP Does Biologically
VIP was characterised as a gut peptide and named for its vasodilatory effect, but its documented roles range considerably wider than the name suggests.
In the digestive system it relaxes smooth muscle, stimulates water and electrolyte secretion into pancreatic juice and bile, and inhibits gastric acid secretion. In the cardiovascular system it produces vasodilation and coronary vasodilation and stimulates cardiac contractility. It regulates prolactin secretion and modulates growth hormone-releasing hormone activity.
The role that draws the most current research interest is circadian. VIP acts as a major synchronising signal among neurons of the suprachiasmatic nucleus — the brain’s central clock — which places it in chronobiology research alongside its older gastrointestinal and cardiovascular literature.
Why Buy VIP 10mg in Canada from a Domestic Research Supplier?
VIP is a 28-residue peptide with several residues prone to oxidation and deamidation, which makes it less forgiving in storage than the short, robust peptides that surround it on a catalogue. Transit time and temperature exposure matter correspondingly more.
Domestic fulfilment shortens the uncontrolled leg of the journey and gives you a Canadian counterparty when a lot does not match its paperwork. Neither replaces checking the material on arrival, and neither is a quality claim about what is in the vial.
How This VIP Canada Page Improves on Typical Competitor Listings
- The half-life leads. Two minutes is the fact that decides whether an experiment is viable, and most listings omit it entirely.
- The receptors are named correctly. VPAC1 and VPAC2, class II GPCRs — not “VIP receptors” left undefined.
- The species question is settled. Human, porcine and rat VIP share a sequence, which resolves a common source of confusion when comparing reports.
- The CAS ambiguity is disclosed rather than papered over with a single confident number.
- No outcome claims. This listing does not describe experiences, results or benefits.
How to Evaluate a VIP Certificate of Analysis
For a 28-residue peptide with oxidation-prone residues, degradation products matter as much as gross purity.
- Named molecule: vasoactive intestinal peptide, ideally with the sequence or a registry number given.
- Mass confirmation: approximately 3.3 kDa.
- Oxidation: the methionine residue is the obvious vulnerability; ask whether oxidised species were resolved.
- Deamidation: whether charge variants were separated, where the assay is sensitive to them.
- Lot reference and date: cross-check both against the vial.
- Reported quantity: should reconcile with the 10mg format.
- Independent check: a verification reference you can put to the issuing laboratory.
Red Leaf publishes Janoshik reports with a verification key. On a peptide this susceptible to oxidation, a purity figure with no impurity profile behind it is a partial answer.
VIP 10mg Lyophilized Research Format
The 10mg vial arrives as a lyophilized cake. Lyophilization describes how the water was removed and implies nothing about identity or purity.
VIP is more sensitive than most short peptides to oxidation, moisture and repeated handling, and it adsorbs to container surfaces at low concentrations — a real source of error when preparing dilute working solutions. Consider low-binding labware and a carrier protein where the assay allows it. Inspect the cake, connect the vial to its analytical report, and follow validated institutional procedures. Background on diluent choice is in bacteriostatic water uses and handling.
Working out concentration for this vial? Our peptide reconstitution calculator converts vial size and bacteriostatic water volume into mg per mL and U-100 syringe units.
How to Buy VIP in Canada for Qualified Research
- Establish eligibility. Confirm the purchaser and institution are authorized to hold research-use material.
- Decide in-vitro or in-vivo first. The two-minute half-life makes this the question that shapes everything downstream.
- Read the report, checking mass and the oxidation profile rather than purity alone.
- Plan for adsorption. Choose labware and carrier conditions before preparing dilute solutions.
- Log it in. Lot reference, arrival condition, storage location, against the study plan.
Fulfilment is to qualified Canadian purchasers by domestic express. Red Leaf supplies material and documentation; it does not advise on study design and provides nothing that supports use in humans or animals.
VIP Availability in Canada: Research vs. Consumer Searches
VIP holds no marketing authorization in Canada as a consumer or clinical product and has not been assessed for consumer safety or effectiveness by Health Canada.
Research supply and public medical availability are separate categories. A vial available to a qualified laboratory is not an approved retail medicine, a treatment, or a substitute for professional care. Anyone searching from a personal health motivation should speak with a licensed clinician rather than a research supplier.
VIP 10mg Canada Procurement Checklist
| Check | What to confirm |
|---|
| Purpose | Authorized laboratory research with an approved study plan |
| Design | In-vitro or in-vivo settled, with the two-minute half-life accounted for |
| Identity | 28-residue VIP, mass near 3.3 kDa, registry number checked against sequence |
| Impurities | Oxidised and deamidated species resolved where relevant |
| Labware | Adsorption accounted for in dilute preparations |
| Verification | Report can be checked against the issuing laboratory |
| Handling | Storage and preparation procedures validated by the receiving institution |
Explore VIP Research Information
For supplier-selection criteria in the Canadian market, review how to evaluate a Canadian research peptide supplier. For a wider survey of compounds studied in this space, see research peptides worth knowing.
VIP research FAQ
What receptors does VIP act on?
VPAC1 and VPAC2, both class II G protein-coupled receptors in the secretin/glucagon receptor family.
Why does the half-life matter so much?
At roughly two minutes in circulation, native VIP cannot sustain systemic exposure. It is a strong in-vitro receptor-pharmacology tool; whole-organism work in this area generally relies on engineered analogues or delivery strategies instead.
Is human VIP different from porcine or rat VIP?
No. The sequences are identical across those species, so a report naming any of them describes the same molecule.
What is the circadian connection?
VIP acts as a major synchronising signal among neurons of the suprachiasmatic nucleus, the brain’s central circadian pacemaker.
Does Red Leaf Research Labs provide dosing information?
No. Red Leaf Research Labs supplies research material and analytical documentation only.
Research use only. VIP supplied by Red Leaf Research Labs is intended for qualified laboratory research. It is not a medicine, not for human or veterinary use, and not for diagnostic or therapeutic application.
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